• 四川大學(xué)華西醫(yī)院普外科（成都610041）;

【摘要】目的 探討胃癌腹膜播散轉(zhuǎn)移的分子機(jī)理。
方法對(duì)近年國(guó)內(nèi)、外有關(guān)胃癌腹膜轉(zhuǎn)移機(jī)理研究方面的文獻(xiàn)進(jìn)行綜述。
結(jié)果胃癌腹膜轉(zhuǎn)移與癌細(xì)胞活性及腹膜特征有關(guān)，并且需要多種黏附分子、蛋白水解酶、細(xì)胞因子及血管生成因子的共同參與。
結(jié)論胃癌腹膜轉(zhuǎn)移是多因子協(xié)同作用的結(jié)果。

引用本文： 何濤,楊志明,伍曉汀. 胃癌腹膜播散轉(zhuǎn)移機(jī)理的研究進(jìn)展△. 中國(guó)普外基礎(chǔ)與臨床雜志, 2005, 12(1): 43-45. doi: 復(fù)制

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2. Yoo CH, Noh SH, Shin DW, et al. Recurrence following curative resection for gastric carcinoma [J]. Br J Surg, 2000; 87(2)∶236.
3. Maehara Y, Hasuda S, Koga T, et al. Postoperative outcome and sites of recurrence in patients following curative resection of gastric cancer [J]. Br J Surg, 2000; 87(3)∶353.
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5. Maehara Y, Tomisaki S, Oda S, et al. Lymphatic advancement to peritoneal dissemination and liver metastasis in gastric cancer patients [J]. Anticancer Res, 1994; 14(6B)∶2755.
6. Tanaka T, Kumagai K, Shimizu K, et al. Peritoneal metastasis in gastric cancer with particular reference to lymphatic advancement; extranodal invasion is a significant risk factor for peritoneal metastasis [J]. J Surg Oncol, 2000; 75(3)∶165.
7. Kiyasu Y, Kaneshima S, Koga S. Morphogenesis of peritoneal metastasis in human gastric cancer [J]. Cancer Res, 1981; 41(3)∶1236.
8. Zhou YN, Xu CP, Han B, et al. Expression of Ecadherin and betacatenin in gastric carcinoma and its correlation with the clinicopathological features and patient survival [J]. World J Gastroenterol, 2002; 8(6)∶987.
9. Yonemura Y, Ninomiya I, Kaji M, et al. Decreased Ecadherin expression correlates with poor survival in patients with gastric cancer [J]. Anal Cell Pathol, 1995; 8(2)∶177.
10. Yashiro M, Chung YS, Nishimura S, et al. Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice [J]. Clin Exp Metastasis, 1996; 14(1)∶43.
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12. Ura H, Denno R, Hirata K, et al. Separate functions of alpha2beta1 and alpha3beta1 integrins in the metastatic process of human gastric carcinoma [J]. Surg Today, 1998; 28(10)∶1001.
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14. Nishimura S, Chung YS, Yashiro M, et al. CD44H plays an important role in peritoneal dissemination of scirrhous gastric cancer cells [J]. Jpn J Cancer Res, 1996; 87(12)∶1235.
15. Benchimol S, Fuks A, Jothy S, et al. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule [J]. Cell, 1989; 57(2)∶327.
16. Feng G, Tan Y. Expression and significance of MMP2 and type IV collagen in gastric cancer [J]. Zhonghua Waike Zazhi, 2000; 38(10)∶775.
17. Yonemura Y, Endou Y, Fujita H, et al. Role of MMP7 in the formation of peritoneal dissemination in gastric cancer [J]. Gastric Cancer, 2000; 3(2)∶63.
18. Senota A, Itoh F, Yamamoto H, et al. Relation of matrilysin messenger RNA expression with invasive activity in human gastric cancer [J]. Clin Exp Metastasis, 1998; 16(4)∶313.
19. Bando E, Yonemura Y, Endou Y, et al. Immunohistochemical study of MTMMP tissue status in gastric carcinoma and correlation with survival analyzed by univariate and multivariate analysis [J]. Oncol Rep, 1998; 5(6)∶1483.
20. Tahara E, Kuniyara H, Yasui W, et al. Abnormal expression growth factors and their receptors in stomach cancer [J]. Gann Monoger Cancer Res, 1994; 42(2)∶163.
21. Tannapfel A, Wittekind C, Tahara E. Effect of hepatocyte growth factor (HGF)/scatter factor (SF) on cell adhesion in gastric cancer [J]. Z Gastroenterol, 1994; 32(2)∶91.
22. Murakami N, Koufuji K, Shirouzu K. Influence of hepatocyte growth factor secreted from fibroblasts on the growth and invasion of scirrhous gastric cancer [J]. Int Surg, 2001; 86(3)∶151.
23. Maeda K, Chung YS, Ogawa Y, et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma [J]. Cancer, 1996; 77(5)∶858.
24. Velikova G, Banks RE, Gearing A, et al. Circulating soluble adhesion molecules Ecadherin, Eselectin, intercellular adhesion molecule1 (ICAM1) and vascular cell adhesion molecule1 (VCAM1) in patients with gastric cancer [J]. Br J Cancer, 1997; 76(11)∶1398.
  1. 1. Tsujitani S, Oka S, Suzuki K, et al. Prognostic factors in patients with advanced gastric cancer treated by noncurative resection: a multivariate analysis [J]. Hepatogastroenterology, 2001; 48(41)∶1504.
  2. 2. Yoo CH, Noh SH, Shin DW, et al. Recurrence following curative resection for gastric carcinoma [J]. Br J Surg, 2000; 87(2)∶236.
  3. 3. Maehara Y, Hasuda S, Koga T, et al. Postoperative outcome and sites of recurrence in patients following curative resection of gastric cancer [J]. Br J Surg, 2000; 87(3)∶353.
  4. 4. Nishimura S, Chung YS, Yashiro M, et al. Role of alpha 2 beta 1and alpha 3 beta 1integrin in the peritoneal implantation of scirrhous gastric carcinoma [J]. Br J Cancer, 1996; 74(9)∶1406.
  5. 5. Maehara Y, Tomisaki S, Oda S, et al. Lymphatic advancement to peritoneal dissemination and liver metastasis in gastric cancer patients [J]. Anticancer Res, 1994; 14(6B)∶2755.
  6. 6. Tanaka T, Kumagai K, Shimizu K, et al. Peritoneal metastasis in gastric cancer with particular reference to lymphatic advancement; extranodal invasion is a significant risk factor for peritoneal metastasis [J]. J Surg Oncol, 2000; 75(3)∶165.
  7. 7. Kiyasu Y, Kaneshima S, Koga S. Morphogenesis of peritoneal metastasis in human gastric cancer [J]. Cancer Res, 1981; 41(3)∶1236.
  8. 8. Zhou YN, Xu CP, Han B, et al. Expression of Ecadherin and betacatenin in gastric carcinoma and its correlation with the clinicopathological features and patient survival [J]. World J Gastroenterol, 2002; 8(6)∶987.
  9. 9. Yonemura Y, Ninomiya I, Kaji M, et al. Decreased Ecadherin expression correlates with poor survival in patients with gastric cancer [J]. Anal Cell Pathol, 1995; 8(2)∶177.
  10. 10. Yashiro M, Chung YS, Nishimura S, et al. Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice [J]. Clin Exp Metastasis, 1996; 14(1)∶43.
  11. 11. Matsuoka T, Yashiro M, Nishimura S, et al. Increased expression of alpha2beta1integrin in the peritoneal dissemination of human gastric carcinoma [J]. Int J Mol Med, 2000; 5(1)∶21.
  12. 12. Ura H, Denno R, Hirata K, et al. Separate functions of alpha2beta1 and alpha3beta1 integrins in the metastatic process of human gastric carcinoma [J]. Surg Today, 1998; 28(10)∶1001.
  13. 13. Nakashio T, Narita T, Sato M, et al. The association of metastasis with the expression of adhesion molecules in cell lines derived from human gastric cancer [J]. Anticancer Res, 1997; 17(1A)∶293.
  14. 14. Nishimura S, Chung YS, Yashiro M, et al. CD44H plays an important role in peritoneal dissemination of scirrhous gastric cancer cells [J]. Jpn J Cancer Res, 1996; 87(12)∶1235.
  15. 15. Benchimol S, Fuks A, Jothy S, et al. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule [J]. Cell, 1989; 57(2)∶327.
  16. 16. Feng G, Tan Y. Expression and significance of MMP2 and type IV collagen in gastric cancer [J]. Zhonghua Waike Zazhi, 2000; 38(10)∶775.
  17. 17. Yonemura Y, Endou Y, Fujita H, et al. Role of MMP7 in the formation of peritoneal dissemination in gastric cancer [J]. Gastric Cancer, 2000; 3(2)∶63.
  18. 18. Senota A, Itoh F, Yamamoto H, et al. Relation of matrilysin messenger RNA expression with invasive activity in human gastric cancer [J]. Clin Exp Metastasis, 1998; 16(4)∶313.
  19. 19. Bando E, Yonemura Y, Endou Y, et al. Immunohistochemical study of MTMMP tissue status in gastric carcinoma and correlation with survival analyzed by univariate and multivariate analysis [J]. Oncol Rep, 1998; 5(6)∶1483.
  20. 20. Tahara E, Kuniyara H, Yasui W, et al. Abnormal expression growth factors and their receptors in stomach cancer [J]. Gann Monoger Cancer Res, 1994; 42(2)∶163.
  21. 21. Tannapfel A, Wittekind C, Tahara E. Effect of hepatocyte growth factor (HGF)/scatter factor (SF) on cell adhesion in gastric cancer [J]. Z Gastroenterol, 1994; 32(2)∶91.
  22. 22. Murakami N, Koufuji K, Shirouzu K. Influence of hepatocyte growth factor secreted from fibroblasts on the growth and invasion of scirrhous gastric cancer [J]. Int Surg, 2001; 86(3)∶151.
  23. 23. Maeda K, Chung YS, Ogawa Y, et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma [J]. Cancer, 1996; 77(5)∶858.
  24. 24. Velikova G, Banks RE, Gearing A, et al. Circulating soluble adhesion molecules Ecadherin, Eselectin, intercellular adhesion molecule1 (ICAM1) and vascular cell adhesion molecule1 (VCAM1) in patients with gastric cancer [J]. Br J Cancer, 1997; 76(11)∶1398.