• 1.浙江省上虞市中醫(yī)院外科（上虞312300）;;
  • 2.上虞市中醫(yī)院檢驗(yàn)科;;
  • 3.浙江省醫(yī)科院（杭州310013）;;
  • 4.浙江省人民醫(yī)院（杭州310014）;

目的研究胃癌組織中CD44v6的表達(dá)以及與腫瘤轉(zhuǎn)移和預(yù)后的關(guān)系。
方法應(yīng)用流式細(xì)胞免疫技術(shù)對52例胃癌組織中CD44v6的表達(dá)進(jìn)行檢測,分析CD44v6的表達(dá)與臨床病理特征的關(guān)系。
結(jié)果新鮮胃癌組織及距癌灶3 cm遠(yuǎn)處的正常胃黏膜組織（經(jīng)病理檢查證實(shí)）中CD44v6的表達(dá)陽性率分別為67.31%(35/52)和25.00（13/52），前者明顯高于后者（P＜0.01)。CD44v6的表達(dá)陽性率與胃癌浸潤深度、淋巴結(jié)轉(zhuǎn)移、遠(yuǎn)處轉(zhuǎn)移及pTNM分期有關(guān)（P＜0.05）。
結(jié)論檢測胃癌組織中CD44v6的表達(dá)對判斷胃癌的浸潤、轉(zhuǎn)移及病期進(jìn)展情況有一定的價值，CD44v6可作為一個預(yù)測胃癌轉(zhuǎn)移潛能和胃癌患者預(yù)后的病理生物學(xué)指標(biāo)之一。

引用本文： 徐勝軍,胡炳奎,凌志強(qiáng),趙挺. CD44v6在胃癌中的表達(dá)及其臨床意義. 中國普外基礎(chǔ)與臨床雜志, 2006, 13(1): 42-44. doi: 復(fù)制

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2. Xin Y, Grace A, Gallagher MM, et al. CD44V6 in gastric carcinoma: a marker of tumor progression [Ｊ]. Appl Immunohistochem Mol Morphol, 2001; 9(2)∶138.
3. Stachura J, Krzeszowiak A, Popiela T, et al. Preferential overexpression of CD44v5 in advanced gastric carcinoma Goseki grades Ⅰ and Ⅲ [Ｊ]. Pol J Pathol, 1999; 50(3)∶155.
4. Van Driel M, Gunthert U, van Kessel AC, et al. CD44 variant isoforms are involved in plasma cell adhesion to bone marrow stromal cells [Ｊ]. Leukemia, 2002; 16(1)∶135.
5. Gulmann C, Grace A, Leader M, et al. CD44v6: a potential marker of malignant transformation in intestinal metaplasia of the stomach? An immunohistochemical study using tissue microarrays [Ｊ]. Eur J Gastroenterol Hepatol, 2003; 15(9)∶981.
6. Joo M, Lee HK, Kang YK. Expression of Ecadherin, betacatenin, CD44s and CD44v6 in gastric adenocarcinoma: relationship with lymph node metastasis [Ｊ]. Anticancer Res, 2003; 23(2B)∶1581.
7. Koyama S, Maruyama T, Adachi S. Expression of epidermal growth factor receptor and CD44 splicing variants sharing exons 6 and 9 on gastric and esophageal carcinomas: a twocolor flowcytometric analysis [Ｊ]. J Cancer Res Clin Oncol, 1999; 125(1)∶47.
8. Nakashio T, Narita T, Sato M, et al. The association of metastasis with the expression of adhesion molecules in cell lines derived from human gastric cancer [Ｊ]. Anticancer Res, 1997; (1A)∶293.
  1. 1. Yamaguchi A, Goi T, Yu J, et al. Expression of CD44v6 in advanced gastric cancer and its relationship to hematogenous metastasis and longterm prognosis [Ｊ]. J Surg Oncol, 2002; 79(4)∶230.
  2. 2. Xin Y, Grace A, Gallagher MM, et al. CD44V6 in gastric carcinoma: a marker of tumor progression [Ｊ]. Appl Immunohistochem Mol Morphol, 2001; 9(2)∶138.
  3. 3. Stachura J, Krzeszowiak A, Popiela T, et al. Preferential overexpression of CD44v5 in advanced gastric carcinoma Goseki grades Ⅰ and Ⅲ [Ｊ]. Pol J Pathol, 1999; 50(3)∶155.
  4. 4. Van Driel M, Gunthert U, van Kessel AC, et al. CD44 variant isoforms are involved in plasma cell adhesion to bone marrow stromal cells [Ｊ]. Leukemia, 2002; 16(1)∶135.
  5. 5. Gulmann C, Grace A, Leader M, et al. CD44v6: a potential marker of malignant transformation in intestinal metaplasia of the stomach? An immunohistochemical study using tissue microarrays [Ｊ]. Eur J Gastroenterol Hepatol, 2003; 15(9)∶981.
  6. 6. Joo M, Lee HK, Kang YK. Expression of Ecadherin, betacatenin, CD44s and CD44v6 in gastric adenocarcinoma: relationship with lymph node metastasis [Ｊ]. Anticancer Res, 2003; 23(2B)∶1581.
  7. 7. Koyama S, Maruyama T, Adachi S. Expression of epidermal growth factor receptor and CD44 splicing variants sharing exons 6 and 9 on gastric and esophageal carcinomas: a twocolor flowcytometric analysis [Ｊ]. J Cancer Res Clin Oncol, 1999; 125(1)∶47.
  8. 8. Nakashio T, Narita T, Sato M, et al. The association of metastasis with the expression of adhesion molecules in cell lines derived from human gastric cancer [Ｊ]. Anticancer Res, 1997; (1A)∶293.