• 1.蘭州大學(xué)第一醫(yī)院普外科（蘭州730000）;;
  • 2.蘭州大學(xué)臨床醫(yī)學(xué)院（蘭州730000）;;
  • 3.蘭州大學(xué)第一醫(yī)院病理科（蘭州730000）;

目的探討胃癌侵襲和轉(zhuǎn)移過程中黏著斑激酶（FAK）的表達(dá)與其生物學(xué)行為的關(guān)系。
方法用免疫組化SABC法檢測(cè)50例行胃癌根治術(shù)所收集的癌組織、癌旁組織、正常胃黏膜組織和胃區(qū)域淋巴結(jié)標(biāo)本中FAK的表達(dá)情況。
結(jié)果FAK表達(dá)強(qiáng)陽性率在胃癌組織中（78.0%）明顯高于正常胃黏膜組織（10.0%）及癌旁組織（20.0%），P＜0.01，正常胃黏膜組織與癌旁組織中的表達(dá)差異無統(tǒng)計(jì)學(xué)意義(P gt;0.05)。FAK表達(dá)強(qiáng)陽性率在淋巴結(jié)有轉(zhuǎn)移和無轉(zhuǎn)移患者中分別是68.8%（22/32）和33.3%（6/18），前者明顯高于后者(P＜0.05)； 在有轉(zhuǎn)移的淋巴結(jié)中和無轉(zhuǎn)移的淋巴結(jié)中分別是87.2%（136/156）和40.9%(18/44),前者明顯高于后者（P＜0.01）； FAK表達(dá)強(qiáng)陽性率與胃癌浸潤深度和分化程度有關(guān)，浸潤深度越深，細(xì)胞分化越低，表達(dá)強(qiáng)陽性率越高(P＜0.05)； 與Borrmann分型、腫瘤部位及大小無關(guān)(P gt;0.05)。
結(jié)論FAK表達(dá)與胃癌發(fā)生、發(fā)展有關(guān)，F(xiàn)AK表達(dá)增高是胃癌細(xì)胞浸潤和轉(zhuǎn)移的重要原因之一，檢測(cè)癌組織中FAK表達(dá)水平,有助于進(jìn)一步了解胃癌的生物學(xué)行為,有利于治療與預(yù)后判斷。

引用本文： 張多強(qiáng),李玉民,何曉東,周文策,李汛,曾峰,楊蘭生. 黏著斑激酶的高表達(dá)與人胃癌侵襲和轉(zhuǎn)移的關(guān)系. 中國普外基礎(chǔ)與臨床雜志, 2006, 13(1): 38-41. doi: 復(fù)制

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  2. 2. Su JM, Gui L, Zhou YP, et al. Expression of focal adhesion kinase and alpha5 and beta1 integrins in carcinomas and its clinical significance [Ｊ]. World J Gastroenterol, 2002; 8(4)∶613.
  3. 3. Duxbury MS, Ito H, Zinner MJ, et al.Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells [Ｊ]. Surgery, 2004; 135(5)∶555.
  4. 4. Crowe DL, Ohannessian A. Recruitment of focal adhesion kinase and paxillin to beta1 integrin promotes cancer cell migration via mitogen activated protein kinase activation [Ｊ]. BMC Cancer, 2004; 4(1)∶18.
  5. 5. Wang H, Radjendirane V, Wary KK, et al. Transforming growth factor beta regulates cellcell adhesion through extracellular matrix remodeling and activation of focal adhesion kinase in human colon carcinoma Moser cells [Ｊ]. Oncogene, 2004; 23(32)∶5558.
  6. 6. Zhang Y, Thant AA, Hiraiwa Y, et al.A role for focal adhesion kinase in hyluronandependent MMP2 secretion in a human smallcell lung carcinoma cell line, QG90 [Ｊ]. Biochem Biophys Res Commun, 2002; 290(3)∶1123.
  7. 7. Fujii T, Koshikawa K, Nomoto S, et al. Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor [Ｊ]. J Hepatol, 2004; 41(1)∶104.