目的 評價術(shù)前立體超選擇性動脈灌注化療在ⅡB~ⅢA期乳腺癌保留乳房手術(shù)中的價值。方法 36例乳腺癌患者,其中ⅡB期10例、ⅢA期26,術(shù)前采用立體超選擇性動脈灌注絲裂霉素、表阿霉素和5-氟尿嘧啶,化療后再進行手術(shù)。結(jié)果 36例患者灌注化療后病灶緩解32例,好轉(zhuǎn)3例,無明顯變化1例; 緩解率達88.9%(32/36),該32例患者腫瘤直徑均縮小到2 cm以下,獲得保乳手術(shù)機會。結(jié)論 術(shù)前立體超選擇性動脈灌注化療可使局部晚期乳腺癌降期獲得保乳機會。
引用本文: 何勁松,朱國獻,郭良峰,陳偉財,周汝明,王先明. 立體超選擇性動脈灌注化療在乳腺癌降期保乳術(shù)中的價值. 中國普外基礎(chǔ)與臨床雜志, 2008, 15(12): 929-930. doi: 復制
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- 1. 王先明, 何勁松, 佟建蒙, 等. 立體超選擇動脈灌注化療在治療晚期乳腺癌中的臨床應(yīng)用 [J]. 外科理論與實踐, 2006; 11(2)∶136.
- 2. 左文述主編. 現(xiàn)代乳腺腫瘤學 [M]. 第2版. 濟南: 山東科學技術(shù)出版社, 2006∶974~979.
- 3. 周永剛, 魏 瑋. 烏金膠囊的制備及臨床療效觀察 [J]. 江蘇藥學與臨床研究, 2004; 12(5)∶47.
- 4. 李 振主編. 惡性腫瘤的化學治療與免疫治療 [M]. 北京: 人民衛(wèi)生出版社, 1994∶59~61.
- 5. Fisher B, Redmond C, Poisson R, et al. Eight-year results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer [J]. N Engl J Med, 1989; 320(13)∶822.
- 6. Staradub VL, Hsieh YC, Clauson J, et al. Factors that influence surgical choices in women with breast carcinoma [J]. Cancer, 2002; 95(6)∶1185.
- 7. Nold RJ, Beamer RL, Helmer SD, et al. Factors influencing a woman’s choice to undergo breast-conserving surgery versus modified radical mastectomy [J]. Am J Surg, 2000; 180(6)∶413.
- 8. 劉力波, 高麗華, 李寬明, 等. 灌注化療栓塞后手術(shù)切除直腸癌31例報告 [J]. 中國普外基礎(chǔ)與臨床雜志, 2005; 12(5)∶512.
- 9. Bilbao JI, Rebollo J, Longo JM, et al. Neoadjuvant intra-arterial chemotherapy in inflammatory carcinoma of the breast [J]. Br J Radiol, 1992; 65(771)∶248.
- 10. Vanel D. Interventional radiology: the new daily work of the breast radiologist [J]. Eur J Radiol, 2002; 42(1)∶1.
- 11. 張保寧, 邵志敏, 喬新民, 等. 中國乳腺癌保乳治療的前瞻性多中心研究 [J]. 中華腫瘤雜志, 2005; 27(11)∶680.
- 12. Xing Y, Foy M, Cox DD, et al. Meta-analysis of sentinel lymph node biopsy after preoperative chemotherapy in patients with breast cancer [J]. Br J Surg, 2006; 93(5)∶539.