• 四川大學(xué)華西醫(yī)院（成都，610041）;

【摘要】　目的　 介紹腸外營養(yǎng)液中的鋁污染。方法　 本文根據(jù)國內(nèi)外文獻(xiàn)，對腸外營養(yǎng)液中的鋁污染進(jìn)行了綜述。結(jié)果　 腸外營養(yǎng)液中的鋁污染研究仍處于探索階段，但已找到了兩個主要來源，給予了一些解決措施。結(jié)論　 重視腸外營養(yǎng)液中的鋁污染，加強(qiáng)腸外營養(yǎng)液的安全使用。

引用本文： 樊新星,徐珽,金朝輝,唐堯. 腸外營養(yǎng)液中的鋁污染. 華西醫(yī)學(xué), 2008, 23(1): 203-204. doi: 復(fù)制

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1. 　Leung FY. Trace elements in parenteral micronutrition[J]. Clin Biochem, 1995, 28(6): 561-566.
2. 　Leung FY, Grace DM, Alfieri MA, et al. Abnormal trace elements in a patient on total parenteral nutrition with normal renal function[J]. Clin Biochem, 1995, 28(3): 297-302.
3. 　Hewitt CD, Savory J, Wills MR. Aspects of aluminum toxicity[J]. Clin Lab Med, 1990, 10(2): 403-422.
4. 　Food and Drug Administration. Aluminum in large and small volume parenterals used in total parenteral nutrition. Fed Regist, 2000, 65(17): 4103-4111.
5. 　Advenier E, Landry C, Colomb V, et al. Aluminum contamination of parenteral nutrition and aluminum loading in children on long-term parenteral nutrition[J]. J Pediatr Gastroenterol Nutr, 2003, 36(4): 448-453.
6. 　Koo WW, Kaplan LA, Horn J, et al. Aluminum in parenteral nutrition solution--sources and possible alternatives[J]. JPEN J Parenter Enteral Nutr, 1986, 10(6): 591-595.
7. 　Recknagel S, Bratter P, Chrissafidou A, et al. Parenteralaluminum loading in critical care medicine. Part 1: aluminum content of infusion solutions and solutions for parenteral nutrition. Infusionsther Transfusionsmed, 1994, 21: 266-273.
8. 　Smith BS, Kothari H, Hayes BD, et al. Effect of additive selection on calculated aluminum content of parenteral nutrient solutions[J]. Am J Health Syst Pharm, 2007, 64(7): 730-739.
9. 　Mouser JF, Wu AH, Herson VC. Aluminum contamination of neonatal parenteral nutrient solutions and additives[J]. Am J Health Syst Pharm, 1998, 55(10): 1071-1072. Comment on: Am J Health Syst Pharm, 1998, 55(2): 150-154.
10. 　Pluhator-Murton MM, Fedorak RN, Audette RJ, et al. Traceelement contamination of total parenteral nutrition. 1. Contribution of componentsolutions[J]. JPEN J Parenter Enteral Nutr, 1999, 23(4): 222-227. [11]　Advenier E, Landry C, Colomb V, et al. Aluminum contamination of parenteral nutrition and aluminum loading in children on long-term parenteral nutrition[J]. J Pediatr Gastroenterol Nutr, 2003, 36(4): 448-453.
11. 　Frey OR, Maier L. Polyethylene vials of calcium gluconate reduce aluminum contamination of TPN[J]. Ann Pharmacother, 2000, 34(6): 811-812.
12. 　馬森. 鋁的生物毒性作用及食品衛(wèi)生[J]. 南平師專學(xué)報, 2004, 23(4): 9-12.
13. 　盛明純. 鋁對人體健康影響的研究進(jìn)展綜述[J]. 安徽預(yù)防醫(yī)學(xué)雜志, 2006, 12(1): 46-48.
14. 　Driscoll M, Driscoll DF. Calculating aluminum content in total parenteral nutrition admixtures[J]. Am J Health Syst Pharm, 2005, 62(3): 312-315.
15. 　[No authors listed]. Parenteral drug products containing aluminum as an ingredient or a contaminant: response to Food and Drug Administration notice of intent and request for information. ASCN/A. S. P. E. N. Working Group on Standards for Aluminum Content of Parenteral Nutrition Solutions[J]. JPEN J Parenter Enteral Nutr, 1991, 15(2): 194-198. Comment in: JPEN J Parenter Enteral Nutr, 1992, 16(1): 92-95.
16. 　Young D. FDA aluminum rule poses challengesfor industry, pharmacists[J]. Am J Health Syst Pharm, 2004, 61(8): 742, 744. [18]　Canada TW. Aluminum exposure through parenteral nutrition formulations: mathematical versus clinical relevance[J]. Am J Health Syst Pharm, 2005, 62(3): 315-318. Erratum in: Am J Health Syst Pharm, 2005, 62(7): 679.
  1. 1. 　Leung FY. Trace elements in parenteral micronutrition[J]. Clin Biochem, 1995, 28(6): 561-566.
  2. 2. 　Leung FY, Grace DM, Alfieri MA, et al. Abnormal trace elements in a patient on total parenteral nutrition with normal renal function[J]. Clin Biochem, 1995, 28(3): 297-302.
  3. 3. 　Hewitt CD, Savory J, Wills MR. Aspects of aluminum toxicity[J]. Clin Lab Med, 1990, 10(2): 403-422.
  4. 4. 　Food and Drug Administration. Aluminum in large and small volume parenterals used in total parenteral nutrition. Fed Regist, 2000, 65(17): 4103-4111.
  5. 5. 　Advenier E, Landry C, Colomb V, et al. Aluminum contamination of parenteral nutrition and aluminum loading in children on long-term parenteral nutrition[J]. J Pediatr Gastroenterol Nutr, 2003, 36(4): 448-453.
  6. 6. 　Koo WW, Kaplan LA, Horn J, et al. Aluminum in parenteral nutrition solution--sources and possible alternatives[J]. JPEN J Parenter Enteral Nutr, 1986, 10(6): 591-595.
  7. 7. 　Recknagel S, Bratter P, Chrissafidou A, et al. Parenteralaluminum loading in critical care medicine. Part 1: aluminum content of infusion solutions and solutions for parenteral nutrition. Infusionsther Transfusionsmed, 1994, 21: 266-273.
  8. 8. 　Smith BS, Kothari H, Hayes BD, et al. Effect of additive selection on calculated aluminum content of parenteral nutrient solutions[J]. Am J Health Syst Pharm, 2007, 64(7): 730-739.
  9. 9. 　Mouser JF, Wu AH, Herson VC. Aluminum contamination of neonatal parenteral nutrient solutions and additives[J]. Am J Health Syst Pharm, 1998, 55(10): 1071-1072. Comment on: Am J Health Syst Pharm, 1998, 55(2): 150-154.
  10. 10. 　Pluhator-Murton MM, Fedorak RN, Audette RJ, et al. Traceelement contamination of total parenteral nutrition. 1. Contribution of componentsolutions[J]. JPEN J Parenter Enteral Nutr, 1999, 23(4): 222-227. [11]　Advenier E, Landry C, Colomb V, et al. Aluminum contamination of parenteral nutrition and aluminum loading in children on long-term parenteral nutrition[J]. J Pediatr Gastroenterol Nutr, 2003, 36(4): 448-453.
  11. 11. 　Frey OR, Maier L. Polyethylene vials of calcium gluconate reduce aluminum contamination of TPN[J]. Ann Pharmacother, 2000, 34(6): 811-812.
  12. 12. 　馬森. 鋁的生物毒性作用及食品衛(wèi)生[J]. 南平師專學(xué)報, 2004, 23(4): 9-12.
  13. 13. 　盛明純. 鋁對人體健康影響的研究進(jìn)展綜述[J]. 安徽預(yù)防醫(yī)學(xué)雜志, 2006, 12(1): 46-48.
  14. 14. 　Driscoll M, Driscoll DF. Calculating aluminum content in total parenteral nutrition admixtures[J]. Am J Health Syst Pharm, 2005, 62(3): 312-315.
  15. 15. 　[No authors listed]. Parenteral drug products containing aluminum as an ingredient or a contaminant: response to Food and Drug Administration notice of intent and request for information. ASCN/A. S. P. E. N. Working Group on Standards for Aluminum Content of Parenteral Nutrition Solutions[J]. JPEN J Parenter Enteral Nutr, 1991, 15(2): 194-198. Comment in: JPEN J Parenter Enteral Nutr, 1992, 16(1): 92-95.
  16. 16. 　Young D. FDA aluminum rule poses challengesfor industry, pharmacists[J]. Am J Health Syst Pharm, 2004, 61(8): 742, 744. [18]　Canada TW. Aluminum exposure through parenteral nutrition formulations: mathematical versus clinical relevance[J]. Am J Health Syst Pharm, 2005, 62(3): 315-318. Erratum in: Am J Health Syst Pharm, 2005, 62(7): 679.