• 四川大學(xué)華西醫(yī)院感染性疾病中心，四川成都 610041;

目的：探討毒蕈中毒所致中毒性肝炎的臨床表現(xiàn)、治療與預(yù)后關(guān)系。方法：對3例急性毒蕈中毒患者進(jìn)行回顧性臨床分析。結(jié)果：3例患者均出現(xiàn)中毒性肝炎，2例經(jīng)治療后好轉(zhuǎn)，1例因多器官功能衰竭死亡。結(jié)論：中毒性肝炎如導(dǎo)致多臟器損害，預(yù)后差；及早洗胃，徹底清除毒物是救治關(guān)鍵；血漿置換治療有一定療效，肝移植是最有效的治療手段。

引用本文： 史映紅,馮萍. 毒蕈中毒致中毒性肝炎3例臨床分析. 華西醫(yī)學(xué), 2008, 23(1): 118-119. doi: 復(fù)制

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12. Mullins ME,Horowitz BZ.The futility of hemoperfusion and hemodialysis in amanita phalloides poisoning[Ｊ].Vet Hum Toxicol,2000,42(2):90．.
  1. 1. [１]Iliev Y,Andonova SA,Kabaliev V.Our experience in the treatment of acute amanita phalloides poisoning[Ｊ].Folia Med (Plovdiv),1999,41(4):30．.
  2. 2. 陳灝珠.實(shí)用內(nèi)科學(xué)[M].第10版，北京:人民衛(wèi)生出版社,1998：711．.
  3. 3. Sanford T,Golomb M.RNA polymerase 2 from wildtype and a-amanitin-resistant strains of Caenorhabditis elegans[Ｊ].J Biol Chem,1983,258(21):12804．〖ＨＪ０．４２ｍｍ〗.
  4. 4. Schumann J,Tiegs G.Pathophysiological mechanisms of TNF during intoxication with natural or man-made toxins[Ｊ]．Toxicology，1999,138:103．.
  5. 5. Leist M,Gantner F，Bohlinger I,et al.murine hepatocyte apoptosis induced in vitro and in vivo by TNF-α requires transcriptional arrest[Ｊ].J Immunol,1994,153(4):1778-1788．.
  6. 6. Laskin DL.Nonparenchymal cells and hepatotoxicity[Ｊ].Semin Liver Dis,1990,10:293．.
  7. 7. Catalina MV,Núnez O,Ponferrada A,et al.Liver failure due to mushroom poisoning:clinical course and new treatment perspectives[Ｊ].Gastroenterol Hepatol,2003,26(7):417-420..
  8. 8. Enjalbert F,Rapior S,Nouguier-Soulé J,et al.Treatment of amatoxin poisoning:20-year retrospective analysis[Ｊ].Toxicol Clini Toxicol,2002,40(6):715-757..
  9. 9. Broussard CN,Aggarwal A,Lacey SR,et al.Mushroom poisoning-from diarrhea to liver transplantation[Ｊ].Am J Gastroenterol,2001,96(11):3195-3198..
  10. 10. Jander S,Bischoff J.Treatment of Amanita phalloides poisoning:I.Retrospective evaluation of plasmapheresis in 21 patients[Ｊ].Ther Apher，2000,4(4):303-307..
  11. 11. 張文武.急診內(nèi)科學(xué)[Ｍ]．第1版，北京:人民衛(wèi)生出版社,2000：568－569．.
  12. 12. Mullins ME,Horowitz BZ.The futility of hemoperfusion and hemodialysis in amanita phalloides poisoning[Ｊ].Vet Hum Toxicol,2000,42(2):90．.