目的:對(duì)原發(fā)性脂肪肝(PFLD)患者及健康對(duì)照的一級(jí)親屬中PFLD發(fā)生情況、胰島素抵抗(HOMA-IR)指數(shù)以及其他相關(guān)代謝指標(biāo)的測(cè)定,了解PFLD是否有家族集聚現(xiàn)象及IR在其發(fā)病中的可能作用。方法:PFLD的診斷依據(jù)B超為脂肪肝并排除繼發(fā)性原因。PFLD家系組(A組)共42例,11個(gè)家庭。選取與A組年齡、性別構(gòu)成及生活方式和經(jīng)濟(jì)狀況相近的健康志愿者家系為對(duì)照組(B組)共14例,4個(gè)家庭。所有受試者均進(jìn)行身高、體重、腰圍、血壓等測(cè)定,行糖耐量試驗(yàn)、胰島素及血脂質(zhì)等檢測(cè),并對(duì)受試者的生活方式及文化程度和經(jīng)濟(jì)狀況行量化打分。結(jié)果:A組PFLD 33例(78.57%,A1組),無(wú)脂肪肝9例(A2組),說(shuō)明有家族集聚現(xiàn)象。與B組相比,A1組的體重指數(shù)、腰圍、舒張壓、血總膽固醇和HOMA-IR指數(shù)顯著高于B組(P<0.05);血高密度脂蛋白膽固醇(HDL-C)顯著低于B(P<0.05);A2組的各項(xiàng)指標(biāo)與B組相比差異無(wú)統(tǒng)計(jì)學(xué)意義,但變化趨勢(shì)呈現(xiàn)出腹型肥胖、IR、代謝紊亂和血壓偏高;而A1組及A2組與B組的生活方式及經(jīng)濟(jì)狀況無(wú)明顯差異。結(jié)論:PFLD具有較強(qiáng)的家族聚發(fā)現(xiàn)象,其IR程度顯著高于對(duì)照組;家族中無(wú)脂肪肝者存在IR相關(guān)的代謝紊亂趨勢(shì)。說(shuō)明某種內(nèi)在或遺傳因素如IR可能與PFLD發(fā)病有關(guān)。
引用本文: 王曉茜,童南偉. 胰島素抵抗與原發(fā)性脂肪肝家族集聚現(xiàn)象的初步研究. 華西醫(yī)學(xué), 2008, 23(1): 45-47. doi: 復(fù)制
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