目的:探討西南地區(qū)雌激素受體α（estrogen receptor α，ERα）基因多態(tài)性與原性肝癌關(guān)系。方法:選擇西南地區(qū)100名原發(fā)性肝癌患者為實(shí)驗組，100名非肝病人群作為對照組。應(yīng)用分子生物學(xué)的方法分析PvuⅡ，XbaⅠ限制性片段長度多態(tài)性（restriction fragment length polymorphism，RFLP）。同時對人雌激素受體基因上游的短串聯(lián)重復(fù)序列（short tandem repeat，STR）進(jìn)行純化、克隆和序列分析，觀察ERα基因多態(tài)性基因型在實(shí)驗組與對照組中的基因型分布。結(jié)果:PvuⅡ和XbaⅠ限制性片段長度多態(tài)性在兩組中均呈多態(tài)性分布。病例組TA13等位基因頻率高于對照組，差異有顯著性，TA15等位基因頻率低于對照組，差異有顯著性。結(jié)論:ERα基因多態(tài)性與原性肝癌有關(guān)，X等位基因可能是其危險因素，P等位基因可能是其保護(hù)因素，TA13等位基因可能是其危險因素，TA15等位基因可能是其保護(hù)因素。
引用本文： 張偉,時德,杜成友,羅放. 雌激素受體α基因PvuⅡ、XbaⅠ、STR多態(tài)性與原性肝癌的關(guān)系. 華西醫(yī)學(xué), 2009, 24(1): 70-73. doi: 復(fù)制
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- 2. Giannitrapani L，Soresi M，La Spada E，et al.Sex hormones and risk of liver tumor[J].Ann N Y Acad Sci，2006，1089:228-236..
- 3. Hernandez J，Balic I，JohnsonPais TL，et al.Association between an estrogen receptor α gene polymorphism and the risk of prostate cancer in black men[J].Urol，2006，175（2）:523-527..
- 4. Grundberg E，Ribom EL，Brndstrm H，et al.A TArepeat polymorphism in the gene for the estrogen receptor ɑ does not correlate with muscle strength or body composition in young adult Swedish women[J].Maturitas，2005，50（3）:153-160..
- 5. Eagon PK，F(xiàn)rancavilla A，Dileo A，et al.Quantitation of estrogen and androgen receptors in hepatocellular carcinoma and adjacent normal human liver[J].Dig Dis Sci，1991，36（9）∶1303..
- 6. Wang AG，Lee KY，Kim SY，et al.The expression of estrogen receptors in hepatocellular carcinoma in Korean patients[J].Yonsei Med J，2006，47（6）:811-816..
- 7. Nilsson M，Naessen S，Dahlman I，et al.Association of estrogen receptor β gene polymorphisms with bulimic disease in women[J].Molecular Psychiatry，2004，9（1）:28-34..
- 8. Chen WC，Wu HC，Lin WC，et al.The association of androgenand oestrogenreceptor gene polymorphisms with urolithiasis in men[J].BJU Int，2001，88（4）:432-436..
- 9. Pollake A，Rokach A，Blumennfeldt A，et al.Association of oestrogen receptor α gene polymorphism with the angiographic extent of coronary artery disease[J].Eur Heart，2004，25（3）:240-245.
- 10. Valdes AM，Slatkin M，F(xiàn)reimer NB.Allele frequencies at microsatellite loci:the tepwise mutation model revisited[J].Genetics，1993，133（3）:737-749.