【摘要】 目的 總結(jié)地震致顱腦傷患者凝血功能及疾病嚴(yán)重程度判別的臨床意義。 方法 2008年5月12-30日,對(duì)收治的地震致顱腦傷患者按GCS評(píng)分分為Ⅰ、Ⅱ、Ⅲ組,Ⅰ組:13~15分10例;Ⅱ組:9~12分21例;Ⅲ組:3~8分9例;另?yè)駟渭冘浗M織挫傷患者9例為對(duì)照組,分別檢測(cè)凝血酶原時(shí)間(PT)、活化部分凝血活酶時(shí)間(APTT)、凝血酶時(shí)間(TT)、纖維蛋白原(FIB)及血小板的指標(biāo)。 結(jié)果 顱腦傷組PT、APTT、TT、FIB、血小板與對(duì)照組比較差異有統(tǒng)計(jì)學(xué)意義;其凝血功能異常變化與疾病嚴(yán)重程度相關(guān)。 結(jié)論 檢測(cè)PT、APTT、TT、FIB及血小板變化可以了解顱腦地震傷者的凝血功能及判斷疾病的嚴(yán)重程度,有助于顱腦地震傷患者的診斷和治療。
引用本文: 成剛,胡宏,劉平,黃海林,許芳,馮貴平,吳華新,徐鵬,張亞梅,彭國(guó)瑞. 地震致顱腦傷患者早期血凝機(jī)制探討. 華西醫(yī)學(xué), 2010, 25(12): 2246-2247. doi: 復(fù)制
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- 3. Hulka F, Mullins RJ, Grank EH. Blunt brain injury activates the coagulation pricess [J]. Arch Surg, 1996, 131(12): 923-927.
- 4. 楊術(shù)真, 李麗娜, 李拴德, 等. 兒童外傷性腦梗塞血漿D-二聚體的動(dòng)態(tài)變化[J]. 中華兒科雜志, 2003, 41(2): 91-93.
- 5. Bounameaux H, Moerloose P. Robes G. Plasma measurement of D-dimer as diagnostic aid in suspected venous thromboembo-lism: an overview [J]. Thromb Haemost, 1994, 71(1): 1.
- 6. Wu XY, Shi XY, Gan JX, et al. Dynamically monitoring tissue factor and tissue factor pathway inhibitor following seconday brain injury[J]. China J Traumatol, 2003, 6(2): 114-117.
- 7. 高李貴, 劉亞宵, 王卉芳, 等. 顱腦損傷急性期血漿凝血因子水平的變化[J]. 西安交通大學(xué)學(xué)報(bào)(醫(yī)學(xué)版), 2003, 24(5): 505-509.
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