【摘要】 目的 評(píng)價(jià)大分割適形放射治療對(duì)腹膜后軟組織腫瘤術(shù)后患者的治療作用。 方法 對(duì)1998年10月-2003年4月收治的16例腹膜后軟組織急性腫瘤術(shù)后患者行大分割適形放射治療，設(shè)計(jì)臨床靶區(qū)等效生物劑量為55～62 Gy，觀察放療后2、5年局部控制率、生存率和無(wú)病生存情況。 結(jié)果 2、5年局部控制率較未行放療患者明顯提高并和其他放射治療方式達(dá)到較高治療劑量者近似；遠(yuǎn)期生存無(wú)改善，無(wú)病生存率較未行放療患者有提高。 結(jié)論 大分割適形放射治療方式對(duì)腹膜后軟組織急性腫瘤術(shù)后患者有較好的局部控制作用，無(wú)瘤生存率有提高，遠(yuǎn)期生存無(wú)改善，無(wú)嚴(yán)重的遠(yuǎn)期放療后遺癥。
【Abstract】 Objective To observe the effect of high-dose three-dimensional conformal radiotherapy combined with surgery on primary retroperitoneal soft tissue sarcoma. Methods A total of 16 patients with primary retroperitoneal soft tissue sarcoma underwent high-dose three-dimensional conformal radiotherapy after sarcoma excision from October 1998 to April 2003. The biologically effective dose was 55-62 Gy for CTV. The local control rate and long-term survival rate and disease free survival after 2 and 5 years were observed. Results The local control rate obviously raised in these patients after 2 and 5 years; but the long-term survival rate didn’t improve and the disease free survival improved in these patients compared with those wasn’t radiated. Conclusion High-dose three-dinensional comfomal radiotherapy is effective on the patients with retroperitoneal soft tissue sarcoma in local control rate and disease free survival, but long-term survival rate is not improved and the side-effect is not serious.
引用本文： 劉煥義,駱建華,潘興國(guó). 手術(shù)結(jié)合大分割適形放射治療腹膜后軟組織惡性腫瘤. 華西醫(yī)學(xué), 2010, 25(12): 2164-2166. doi: 復(fù)制
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- 2. Voros D, Theodorou D, Ventouri K, et al. Retroperitoneal tumors: do the satellite tumors mean something? [J]. J Surg Oncol, 1998, 68(1): 30-33.
- 3. Stoeckle E, Coindre M, Bonvalot S, et al. Prognostic factors in retroperitoneal sarcoma a multivariate analysis of a series of 165 patients of the French Cancer Center Federation Sarcoma Group[J]. Cancer, 2001, 92(2): 359-368.
- 4. 劉士新, 王佳銘, 何若吉, 等. 76例軟組織肉瘤術(shù)后放療的臨床觀察[J]. 實(shí)用腫瘤學(xué)雜志, 2001, 15(1): 40-41.
- 5. Mendenhall WM, Zlotechi RA, Hochwald SN, et al. Retroperitoneal soft tissue sarcoma[J]. Cancer, 2005, 104(4): 669-756.
- 6. 王淑蓮, 劉新帆, 李曄雄, 等. 75例腹膜后軟組織肉瘤的臨床分析[J] 中華放射腫瘤學(xué)雜志, 2004, 13(4): 298-301.
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