• 四川大學華西醫(yī)院腎臟內科（成都，610041）;

【摘要】　目的　 探討米諾地爾對血液透析伴頑固性高血壓的降壓價值。　方法　 觀察1例血液透析伴頑固性高血壓患者米諾地爾的降壓療效，分析米諾地爾的臨床應用及不良反應。　結果　 米諾地爾能快速高效地控制患者的頑固性高血壓狀態(tài)，且小劑量長期維持治療未發(fā)生明顯藥物相關副作用。　結論　 米諾地爾降壓效果顯著、起效迅速，但鑒于使用米諾地爾的潛在毒副作用較多，該藥應該被嚴格限制到對足量傳統(tǒng)降壓藥無效或伴有不能接受的藥物并發(fā)癥患者。

引用本文： 田茂露,劉曉霞,胡章學. 米諾地爾治療血液透析伴頑固性高血壓一例. 華西醫(yī)學, 2011, 26(12): 1870-1871. doi: 復制

1. 　Mahony JF, Gibson GR, Sheil AG, et al. Bilateral nephrectomy for malignant hypertension[J]. Lancet, 1972, 299(7759): 1036-1038.
2. 　Pettinger WA, Mitchell HC. Minoxidil--an alternative to nephrectomy for refractory hypertension[J]. N Engl J Med, 1973, 289(4): 167-171.
3. 　Black RN, Hunter SJ, Atkinson AB. Usefulness of the vasodilator minoxidil in resistant hypertension[J]. J Hypertens, 2007, 25(5): 1102-1103.
4. 　Halling SE, Asling-Monemi K, Herthelius M, et al. Minoxidil therapy in children and young adult patients with renal disease and refractory hypertension: value when multidrug regimens have failed to achieve blood pressure control[J]. J Hum Hypertens, 2010, 24(8): 552-554.
5. 　Black RNA, Hunter SJ, Atkinson AB. Refractory hypertension can often be helped by the use of the potent vasodilator minoxidil: results in 13 patients, 12 of whom were already receiving angiotensin converting enzyme inhibitors or angiotensin II receptor antagonists[J]. Endocrine Abstracts, 2005, 9: 12.
6. 　劉雙信, 史偉, 梁馨苓, 等. 米諾地爾在治療血液透析伴頑固性高血壓中的應用[J]. 中國血液凈化, 2004, 7(3): 355-357.
7. 　Javier R, Dumler F, Park JH, et al. Long-term treatment with minoxidil in patients with severe renal failure[J]. J Cardiovasc Pharmacol, 1980, 2(Suppl 2): S149-S155.
8. 　Luft FC, Bloch R, Szwed JJ, et al. Minoxidil treatment of malignant hypertension: Recovery of renal function[J]. JAMA, 1978, 240(18): 1985-1987.
9. 　Gottlieb TB, Katz FH, Chidsey CA 3rd. Combined therapy with vasodilator drugs and beta-adrenergic blockade in hypertension: a comparative study of minoxidil and hydralazine[J]. Circulation, 1972, 45(3): 571-582.
10. 　McChesney JA, Amend WJ Jr. Minoxidil in the treatment of refractory hypertension due to a spectrum of causes[J]. J Cardiovasc Pharmacol, 1980, 2(Suppl 2): 131-141.
11. 　Mitchell HC, Pettinger WA. Long-term treatment of refractory hypertensive patients with minoxidil[J]. JAMA, 1978, 239(20): 2131-2138.
12. 　Earhart RN, Ball J, Nuss DD, et al. Minoxidil-induced hypertrichosis: treatment with calcium thioglycolate depilatory[J]. South Med J, 1977, 70(4): 442-443.
13. 　Gilmore E, Weil J, Chidsey C. Treatment of essential hypertension with a new vasodilator in combination with beta adrenergic blockade [J]. N Engl J Med, 1970, 282(10): 521-527.
14. 　Zarate A, Gelfand MC, Horton JD, et al. Pericardial effusion associated with minoxidil therapy in dialyzed patients[J]. Int J Artif Organs, 1980, 3(1): 15-17.
15. 　Hall D, Froer DH, Loracher C. Treatment of severe hypertension with minoxidil and its effects on systemic and pulmonary haemodynamics[J]. Clin Sci Mol Med Suppl, 1976, 3: 587-589.
  1. 1. 　Mahony JF, Gibson GR, Sheil AG, et al. Bilateral nephrectomy for malignant hypertension[J]. Lancet, 1972, 299(7759): 1036-1038.
  2. 2. 　Pettinger WA, Mitchell HC. Minoxidil--an alternative to nephrectomy for refractory hypertension[J]. N Engl J Med, 1973, 289(4): 167-171.
  3. 3. 　Black RN, Hunter SJ, Atkinson AB. Usefulness of the vasodilator minoxidil in resistant hypertension[J]. J Hypertens, 2007, 25(5): 1102-1103.
  4. 4. 　Halling SE, Asling-Monemi K, Herthelius M, et al. Minoxidil therapy in children and young adult patients with renal disease and refractory hypertension: value when multidrug regimens have failed to achieve blood pressure control[J]. J Hum Hypertens, 2010, 24(8): 552-554.
  5. 5. 　Black RNA, Hunter SJ, Atkinson AB. Refractory hypertension can often be helped by the use of the potent vasodilator minoxidil: results in 13 patients, 12 of whom were already receiving angiotensin converting enzyme inhibitors or angiotensin II receptor antagonists[J]. Endocrine Abstracts, 2005, 9: 12.
  6. 6. 　劉雙信, 史偉, 梁馨苓, 等. 米諾地爾在治療血液透析伴頑固性高血壓中的應用[J]. 中國血液凈化, 2004, 7(3): 355-357.
  7. 7. 　Javier R, Dumler F, Park JH, et al. Long-term treatment with minoxidil in patients with severe renal failure[J]. J Cardiovasc Pharmacol, 1980, 2(Suppl 2): S149-S155.
  8. 8. 　Luft FC, Bloch R, Szwed JJ, et al. Minoxidil treatment of malignant hypertension: Recovery of renal function[J]. JAMA, 1978, 240(18): 1985-1987.
  9. 9. 　Gottlieb TB, Katz FH, Chidsey CA 3rd. Combined therapy with vasodilator drugs and beta-adrenergic blockade in hypertension: a comparative study of minoxidil and hydralazine[J]. Circulation, 1972, 45(3): 571-582.
  10. 10. 　McChesney JA, Amend WJ Jr. Minoxidil in the treatment of refractory hypertension due to a spectrum of causes[J]. J Cardiovasc Pharmacol, 1980, 2(Suppl 2): 131-141.
  11. 11. 　Mitchell HC, Pettinger WA. Long-term treatment of refractory hypertensive patients with minoxidil[J]. JAMA, 1978, 239(20): 2131-2138.
  12. 12. 　Earhart RN, Ball J, Nuss DD, et al. Minoxidil-induced hypertrichosis: treatment with calcium thioglycolate depilatory[J]. South Med J, 1977, 70(4): 442-443.
  13. 13. 　Gilmore E, Weil J, Chidsey C. Treatment of essential hypertension with a new vasodilator in combination with beta adrenergic blockade [J]. N Engl J Med, 1970, 282(10): 521-527.
  14. 14. 　Zarate A, Gelfand MC, Horton JD, et al. Pericardial effusion associated with minoxidil therapy in dialyzed patients[J]. Int J Artif Organs, 1980, 3(1): 15-17.
  15. 15. 　Hall D, Froer DH, Loracher C. Treatment of severe hypertension with minoxidil and its effects on systemic and pulmonary haemodynamics[J]. Clin Sci Mol Med Suppl, 1976, 3: 587-589.