• 武漢市中醫(yī)醫(yī)院骨傷科（武漢，430014）;

目的 　探討鹽酸氨基葡萄糖聯(lián)合降鈣素對絕經(jīng)后膝骨關(guān)節(jié)炎基質(zhì)金屬蛋白酶3（MMP-3）和骨橋蛋白（OPN）表達(dá)的影響。 方法 　2012年1月－6月將120例絕經(jīng)后膝骨關(guān)節(jié)炎婦女隨機(jī)分為鹽酸氨基葡萄糖組（A組）、鹽酸氨基葡萄糖+依降鈣素組（B組）、依降鈣素組（C組），每組40例，采用酶聯(lián)免疫吸附試驗(yàn)測定各組血清MMP-3、OPN、雌二醇、Ⅰ型膠原C端肽（CTX）和Ⅰ型膠原N端前肽（PINP）水平。 結(jié)果 　A組和B組在治療后2周和6周其膝關(guān)節(jié)評分和視覺模擬評分明顯優(yōu)于C組（P＜0.05），A組在治療后2周MMP-3的表達(dá)改善明顯（P＜0.05），優(yōu)于其他兩組。治療后6周，B組OPN表達(dá)水平改善明顯（P＜0.05），優(yōu)于其他兩組。C組和B組CTX和PINP水平明顯改善（P＜0.05），優(yōu)于A組。 結(jié)論 　鹽酸氨基葡萄糖聯(lián)合降鈣素能有效改善絕經(jīng)后膝骨關(guān)節(jié)炎的癥狀，可能通過調(diào)節(jié)MMP-3和OPN的復(fù)合體表達(dá)，實(shí)現(xiàn)改善關(guān)節(jié)軟骨功能的目的。

引用本文： 戴燚,楊歡,張漢慶,董曉俊,丑鋼. 鹽酸氨基葡萄糖聯(lián)合降鈣素對絕經(jīng)后膝骨關(guān)節(jié)炎基質(zhì)金屬蛋白酶3和骨橋蛋白表達(dá)的影響. 華西醫(yī)學(xué), 2012, 27(12): 1772-1775. doi: 復(fù)制

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2. 　Oshima Y, Matsuda K, Yoshida A, et al. Localization of estrogen receptors alpha and beta in the articular surface of the rat femur[J]. Acta Histochem Cytochem, 2007, 40(1): 27-34.
3. 　Roman-Blas JA, Stokes DG, Jimenez SA. Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes[J]. Osteoarthritis Cartilage, 2007, 15(12): 1367-1377.
4. 　Sowers MR, Mcconnell D, Jannausch M, et al. Estradiol and its metabolites and their association with knee osteoarthritis[J]. Arthritis Rheum, 2006, 54(8): 2481-2487.
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7. 　李偉, 潘曉華. 雌激素受體與骨性關(guān)節(jié)炎相關(guān)性研究進(jìn)展[J]. 廣東醫(yī)學(xué), 2011, 32(19): 2601-2604.
8. 　Kusano K, Miyaura C, Inada M, et al. Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption[J]. Endocrinology, 1998, 139(3): 1338-1345.
9. 　戴燚, 殷濤, 李浩, 等. 絕經(jīng)后婦女基質(zhì)金屬蛋白酶3和抑制因子水平及其與骨密度和骨橋蛋白的關(guān)系[J]. 中國骨質(zhì)疏松雜志, 2011, 17(8): 661-664, 673.
10. 　Behets C, Williams JM, Chappard D, et al. Effects of calcitonin on subchondral trabecular bone changes and on osteoarthritic cartilage lesions after acute anterior cruciate ligament deficiency[J]. J Bone Miner Res, 2004, 19(11): 1821-1826.
11. 　張漢慶, 戴燚, 李浩, 等. 絕經(jīng)后婦女骨代謝過程中血清基質(zhì)金屬蛋白酶3和骨橋蛋白的變化[J]. 中國組織工程研究與臨床康復(fù), 2011, 15(41): 7783-7786.
12. 　戴燚, 李浩, 王度, 等. MMP-3和OPN水平與絕經(jīng)后骨質(zhì)疏松癥的相關(guān)性[J]. 中國民族民間醫(yī)藥, 2011, 20(21): 42-43.
13. 　Fujikawa Y, Sabokbar A, Neale SD, et al. The effect of macrophage-colony stimulating factor and other humoral factors (interleukin-1, -3, -6, and -11, tumor necrosis factor-alpha, and granulocyte macrophage-colony stimulating factor) on human osteoclast formation from circulating cells[J]. Bone, 2001, 28(3): 261-267.
14. 　Karsdal MA, Tanko LB, Riis BJ, et al. Calcitonin is involved in cartilage homeostasis:is calcitonin atreatment for OA? [J].Osteoarthritis Cartilage, 2006, 14(7): 617-624.
15. 　Burr DB. Subchondral bone in the pathogenesis of osteoarthritis[M]. New York : oxford university press, 2003: 125-133.
16. 　Papfioannou NA, Triantaflllopouios IK, Khaldik, et al. Effect of caicitonin in early and late stages of experimentally induced osteoarthritis[J]. Osteoarthritis Cartilage, 2011, 15(4): 386-395.
17. 　周黎, 戴燚, 李浩, 等. 絕經(jīng)后婦女基質(zhì)金屬蛋白酶-3和骨橋蛋白水平與骨密度和骨保護(hù)蛋白及其配體的相關(guān)性研究[J]. 湖北中醫(yī)藥大學(xué)學(xué)報(bào), 2012, 14(2): 60-62.
  1. 1. 　Lidgren L. The bone and joint decade and the global economic and healthcare burden of musculoskeletal disease[J]. J Rheumatol Suppl, 2003, 67(67): 4-5.
  2. 2. 　Oshima Y, Matsuda K, Yoshida A, et al. Localization of estrogen receptors alpha and beta in the articular surface of the rat femur[J]. Acta Histochem Cytochem, 2007, 40(1): 27-34.
  3. 3. 　Roman-Blas JA, Stokes DG, Jimenez SA. Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes[J]. Osteoarthritis Cartilage, 2007, 15(12): 1367-1377.
  4. 4. 　Sowers MR, Mcconnell D, Jannausch M, et al. Estradiol and its metabolites and their association with knee osteoarthritis[J]. Arthritis Rheum, 2006, 54(8): 2481-2487.
  5. 5. 　王亦璁. 膝關(guān)節(jié)外科的基礎(chǔ)和臨床[M]. 北京: 人民衛(wèi)生出版社, 1999: 551-552.
  6. 6. 　趙延斌, 林伍伍. 鹽酸氨基葡萄糖膠囊治療膝骨關(guān)節(jié)炎療效觀察[J]. 中國藥師, 2011, 14(9): 1314-1315.
  7. 7. 　李偉, 潘曉華. 雌激素受體與骨性關(guān)節(jié)炎相關(guān)性研究進(jìn)展[J]. 廣東醫(yī)學(xué), 2011, 32(19): 2601-2604.
  8. 8. 　Kusano K, Miyaura C, Inada M, et al. Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption[J]. Endocrinology, 1998, 139(3): 1338-1345.
  9. 9. 　戴燚, 殷濤, 李浩, 等. 絕經(jīng)后婦女基質(zhì)金屬蛋白酶3和抑制因子水平及其與骨密度和骨橋蛋白的關(guān)系[J]. 中國骨質(zhì)疏松雜志, 2011, 17(8): 661-664, 673.
  10. 10. 　Behets C, Williams JM, Chappard D, et al. Effects of calcitonin on subchondral trabecular bone changes and on osteoarthritic cartilage lesions after acute anterior cruciate ligament deficiency[J]. J Bone Miner Res, 2004, 19(11): 1821-1826.
  11. 11. 　張漢慶, 戴燚, 李浩, 等. 絕經(jīng)后婦女骨代謝過程中血清基質(zhì)金屬蛋白酶3和骨橋蛋白的變化[J]. 中國組織工程研究與臨床康復(fù), 2011, 15(41): 7783-7786.
  12. 12. 　戴燚, 李浩, 王度, 等. MMP-3和OPN水平與絕經(jīng)后骨質(zhì)疏松癥的相關(guān)性[J]. 中國民族民間醫(yī)藥, 2011, 20(21): 42-43.
  13. 13. 　Fujikawa Y, Sabokbar A, Neale SD, et al. The effect of macrophage-colony stimulating factor and other humoral factors (interleukin-1, -3, -6, and -11, tumor necrosis factor-alpha, and granulocyte macrophage-colony stimulating factor) on human osteoclast formation from circulating cells[J]. Bone, 2001, 28(3): 261-267.
  14. 14. 　Karsdal MA, Tanko LB, Riis BJ, et al. Calcitonin is involved in cartilage homeostasis:is calcitonin atreatment for OA? [J].Osteoarthritis Cartilage, 2006, 14(7): 617-624.
  15. 15. 　Burr DB. Subchondral bone in the pathogenesis of osteoarthritis[M]. New York : oxford university press, 2003: 125-133.
  16. 16. 　Papfioannou NA, Triantaflllopouios IK, Khaldik, et al. Effect of caicitonin in early and late stages of experimentally induced osteoarthritis[J]. Osteoarthritis Cartilage, 2011, 15(4): 386-395.
  17. 17. 　周黎, 戴燚, 李浩, 等. 絕經(jīng)后婦女基質(zhì)金屬蛋白酶-3和骨橋蛋白水平與骨密度和骨保護(hù)蛋白及其配體的相關(guān)性研究[J]. 湖北中醫(yī)藥大學(xué)學(xué)報(bào), 2012, 14(2): 60-62.