XRCC3基因Thr241Met多态性与中国人肺癌易感性关系的Meta分析_《中国循证医学杂志》

作者：

郑巧玲 , 张含琼 , 张承 ,  徐刚

四川省成都市双流县第一人民医院内四科（成都 610200）;

关键词：

XRCC3 基因多态性中国人肺癌 Meta分析

DOI：

10.7507/1672-2531.20130185

视频：

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摘要 全文 图表 视频 参考文献 施引文献 补充材料

目的　系统评价XRCC3基因Thr241Met多态性与中国人肺癌发病风险的相关性。
方法　计算机检索PubMed、EMbase、CNKI、VIP和WanFang Data，查找国内外关于XRCC3基因Thr241Met多态性与中国人群肺癌易感性关系的研究，检索时限均为建库至2013年8月20日。由2名评价者根据纳入与排除标准独立筛选文献，提取资料并评价质量后，采用RevMan 5.0软件和Stata 10.0软件进行Meta分析，采用Egger’s线性回归法分析发表偏倚。
结果　最终纳入5个研究，包括肺癌患者2 999例，对照2 994例。Meta分析结果显示：对于中国人群而言，携带XRCC3基因Thr241Met多态性突变基因型/等位基因的个体肺癌发病风险不会明显增加：Met/Met vs. Thr/Thr：OR=1.00，95%CI（0.38，2.59），P=0.99；Met/Met vs. Thr/Met：OR=1.06，95%CI（0.83，1.36），P=0.63；Met/Met vs. Thr/Met+Thr/Thr：OR=0.99，95%CI（0.38，2.57），P=0.98；Thr/Met+Met/Met vs. Thr/Thr：OR=1.06，95%CI（0.82，1.37），P=0.65；Met vs. Thr：OR=1.05，95%CI（0.82，1.35），P=0.68。
结论　目前尚未发现XRCC3基因Thr241Met多态性与中国人群肺癌发病风险相关。受纳入研究数量的限制，上述结论需更多高质量大样本研究进一步验证。

引用本文： 郑巧玲,张含琼,张承,徐刚. XRCC3基因Thr241Met多态性与中国人肺癌易感性关系的Meta分析. 中国循证医学杂志, 2013, 13(9): 1080-1083. doi: 10.7507/1672-2531.20130185 复制

1.	Chen Z, Xu L, Ye X, et al. Polymorphisms of microRNA sequences or binding sites and lung cancer: a meta-analysis and systematic review. PloS One, 2013, 8(4): e61008.
2.	Jacobsen NR, Raaschou-Nielsen O, Nexo B, et al. XRCC3 polymorphisms and risk of lung cancer. Cancer lett, 2004, 213(1): 67-72.
3.	Jeon HS, Jin G, Kang HG, et al. A Functional Variant at 19q13.3, rs967591G>A, Is Associated with Shorter Survival of Early-Stage Lung Cancer. Clin Cancer Res, 2013, 19(15): 4185-4195.
4.	Liu ZB, Shu J, Wang LP, et al. Cytochrome P450 2A6 deletion polymorphism and risk of lung cancer: a meta-analysis. Mol Bio Rep, 2013, 40(9): 5255-5259.
5.	Manuguerra M, Saletta F, Karagas MR, et al. XRCC3 and XPD/ERCC2 single nucleotide polymorphisms and the risk of cancer: a HuGE review. Am J Epidemiol, 2006, 164(4): 297-302.
6.	Qian B, Zhang H, Zhang L, et al. Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk. Lung Cancer, 2011, 73(2): 138-146.
7.	Ryk C, Kumar R, Thirumaran RK, et al. Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers. Lung Cancer, 2006, 54(3): 285-292.
8.	Sun H, Qiao Y, Zhang X, et al. XRCC3 Thr241Met polymorphism with lung cancer and bladder cancer: a meta-analysis. Cancer Sci, 2010, 101(8): 1777-1782.
9.	Wang Y, Liang D, Spitz MR, et al. XRCC3 genetic polymorphism, smoking, and lung carcinoma risk in minority populations. Cancer, 2003, 98(8): 1701-1706.
10.	Guo SJ, Li XB, Gao M, et al. The relationship between XRCC1 and XRCC3 gene polymorphisms and lung cancer risk in northeastern Chinese. PloS One, 2013, 8(2): e56213.
11.	Qian BY, Zhang H, Zhang LN, et al. Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk. Lung Cancer, 2011, 73(2): 138-146.
12.	夏文进, 张毅敏, 苏丹, 等. 人类XRCC3-241单核苷酸多态性与非小细胞性肺癌的易感性研究. 浙江医学, 2008, 30(12): 1291-1293.
13.	陈晓雯, 李玲, 杨声杰. PC-1基因外显子4多态性与中国人2型糖尿病相关性的系统评价. 中国循证医学杂志, 2013, 13(3): 308-312.
14.	张本龙, 施小柯. 雌激素受体α基因多态性与中国女性子宫内膜异位症相关性的系统评价. 中国循证医学杂志, 2013, 13(3): 320-324.
15.	Zhang YG, Li XB, Zhang J, et al. The I/D polymorphism of angiotensin-converting enzyme gene and asthma risk: a meta-analysis. Allergy, 2011, 66(2): 197-205.
16.	冉恒泉, 周勇, 陈博, 等. MDM2-309 T>G 基因多态性与东亚人群胃癌风险关系的Meta分析. 中国循证医学杂志, 2013, 13(5): 560-3.
17.	黄萌. XRCC3基因多态性、环境与肺癌的关联. 学位论文: 福建医科大学, 2010.
18.	梁刚. DNA修复基因和致癌物代谢基因单核苷酸多态与肺癌遗传易感性. 学位论文: 中国协和医科大学, 2004.
19.	Yin J, Vogel U, Ma Y, et al. HapMap-based study of the DNA repair gene ERCC2 and lung cancer susceptibility in a Chinese population. Carcinogenesis, 2009, 30(7): 1181-1185.
20.	Liu D, Wang F, Guo X, et al. Association between p53 codon 72 genetic polymorphisms and tobacco use and lung cancer risk in a Chinese population. Mol Bio Rep, 2013, 40(1): 645-649.
21.	Chen J, Zhao QW, Shi GM, et al. XRCC1 Arg399Gln and clinical outcome of platinum-based treatment for advanced non-small cell lung cancer: a meta-analysis in 17 studies. Journal of Zhejiang University Science B, 2012, 13(11): 875-883.

1. Chen Z, Xu L, Ye X, et al. Polymorphisms of microRNA sequences or binding sites and lung cancer: a meta-analysis and systematic review. PloS One, 2013, 8(4): e61008.
2. Jacobsen NR, Raaschou-Nielsen O, Nexo B, et al. XRCC3 polymorphisms and risk of lung cancer. Cancer lett, 2004, 213(1): 67-72.
3. Jeon HS, Jin G, Kang HG, et al. A Functional Variant at 19q13.3, rs967591G>A, Is Associated with Shorter Survival of Early-Stage Lung Cancer. Clin Cancer Res, 2013, 19(15): 4185-4195.
4. Liu ZB, Shu J, Wang LP, et al. Cytochrome P450 2A6 deletion polymorphism and risk of lung cancer: a meta-analysis. Mol Bio Rep, 2013, 40(9): 5255-5259.
5. Manuguerra M, Saletta F, Karagas MR, et al. XRCC3 and XPD/ERCC2 single nucleotide polymorphisms and the risk of cancer: a HuGE review. Am J Epidemiol, 2006, 164(4): 297-302.
6. Qian B, Zhang H, Zhang L, et al. Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk. Lung Cancer, 2011, 73(2): 138-146.
7. Ryk C, Kumar R, Thirumaran RK, et al. Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers. Lung Cancer, 2006, 54(3): 285-292.
8. Sun H, Qiao Y, Zhang X, et al. XRCC3 Thr241Met polymorphism with lung cancer and bladder cancer: a meta-analysis. Cancer Sci, 2010, 101(8): 1777-1782.
9. Wang Y, Liang D, Spitz MR, et al. XRCC3 genetic polymorphism, smoking, and lung carcinoma risk in minority populations. Cancer, 2003, 98(8): 1701-1706.
10. Guo SJ, Li XB, Gao M, et al. The relationship between XRCC1 and XRCC3 gene polymorphisms and lung cancer risk in northeastern Chinese. PloS One, 2013, 8(2): e56213.
11. Qian BY, Zhang H, Zhang LN, et al. Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk. Lung Cancer, 2011, 73(2): 138-146.
12. 夏文进, 张毅敏, 苏丹, 等. 人类XRCC3-241单核苷酸多态性与非小细胞性肺癌的易感性研究. 浙江医学, 2008, 30(12): 1291-1293.
13. 陈晓雯, 李玲, 杨声杰. PC-1基因外显子4多态性与中国人2型糖尿病相关性的系统评价. 中国循证医学杂志, 2013, 13(3): 308-312.
14. 张本龙, 施小柯. 雌激素受体α基因多态性与中国女性子宫内膜异位症相关性的系统评价. 中国循证医学杂志, 2013, 13(3): 320-324.
15. Zhang YG, Li XB, Zhang J, et al. The I/D polymorphism of angiotensin-converting enzyme gene and asthma risk: a meta-analysis. Allergy, 2011, 66(2): 197-205.
16. 冉恒泉, 周勇, 陈博, 等. MDM2-309 T>G 基因多态性与东亚人群胃癌风险关系的Meta分析. 中国循证医学杂志, 2013, 13(5): 560-3.
17. 黄萌. XRCC3基因多态性、环境与肺癌的关联. 学位论文: 福建医科大学, 2010.
18. 梁刚. DNA修复基因和致癌物代谢基因单核苷酸多态与肺癌遗传易感性. 学位论文: 中国协和医科大学, 2004.
19. Yin J, Vogel U, Ma Y, et al. HapMap-based study of the DNA repair gene ERCC2 and lung cancer susceptibility in a Chinese population. Carcinogenesis, 2009, 30(7): 1181-1185.
20. Liu D, Wang F, Guo X, et al. Association between p53 codon 72 genetic polymorphisms and tobacco use and lung cancer risk in a Chinese population. Mol Bio Rep, 2013, 40(1): 645-649.
21. Chen J, Zhao QW, Shi GM, et al. XRCC1 Arg399Gln and clinical outcome of platinum-based treatment for advanced non-small cell lung cancer: a meta-analysis in 17 studies. Journal of Zhejiang University Science B, 2012, 13(11): 875-883.

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XRCC3基因Thr241Met多态性与中国人肺癌易感性关系的Meta分析

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XRCC3基因Thr241Met多态性与中国人肺癌易感性关系的Meta分析

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